Hematological and Morphological changes of blood cells in HIV Patients
Karthik Kasireddy1, *Manjula K2, Prasad CSBR3
1Assistant professor, Department of Pathology, Kamineni Institute of Medical Sciences, NKP, Telangana, 2Associate professor,
Department of Pathology, Sri Devaraj Urs Medical College, Kolar, Karnataka, 3
Professor and HOD, Department of Pathology, Sri
Devaraj Urs Medical College, Kolar, Karnataka
Background: :The Human Immunodeficiency Virus infection causes the Acquired Immunodeficiency
Syndrome. Besides infectious complications, several peripheral blood cell abnormalities have been reported
in HIV infection, of which anaemia and Neutropenia are reportedly the most common, which may have a
considerable impact on the patient’s wellbeing, and treatment.
Material and methods: Blood smears from 101 confirmed newly diagnosed HIV Positive cases were studied
after taking a Written informed consent. Descriptive statistics, chi square test and contingency coefficient
analysis was done using SPSS (version 16) for windows.
Results: HIV Infection affected the highly reproductive age group of 21-40 years with male predominance.
Among the hematological manifestations, anemia (54.5 %) was the commonest among the patients which
is predominantly Normocytic Normochromic anemia. Among the morphological changes the commonest
morphological finding observed was dysplastic neutrophils.
Conclusion: There was significant statistical correlation between declining CD4 counts and Normocytic
anemia, leucopenia and Thrombocytopenia. Hence all HIV Patients should be investigated for complete blood
count including hematologic and morphological assessment of blood cells to reduce mortality and morbidity.