APLA NEGATIVE APLAS
Kodi. Vinuthna,1, Madhumitha choudhary2, Madhava Sai Sivapuram3
1Post Graduate, Department of General Medicine, Kamineni Institute of Medical Sciences, Narketpally, Telangana
2 Department of General Medicine, IQ City Medical College, Durgapur, West Bengal.
3* Department of General Medicine, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinna-Avutapalli, Andhra Pradesh.
Background: Antiphospholipid antibody syndrome (APLAS) is a clinical condition characterized by recurrent vascular thrombosis along with pregnancy-related complications with raised antibodies against phospholipids. Very rarely we come across a clinical profile of APLAS but not satisfying the diagnostic criteria, such cases are termed as seronegative APLAS. Case presentation: A 28 Years old female presented to the emergency with altered sensorium and slurring of speech for one week. The patient has a significant history of two abortions and a pre-term delivery. Following that she developed acute kidney injury which progressed to chronic kidney disease (CKD). For CKD patient is still on dialysis. Diagnostic workup showed negative antibodies for the phospholipids. Due to the clinical significant history and symptoms with negative diagnostic workup, it was diagnosed as seronegative APLAS.